近年来，江苏省中药药效与安全性评价重点实验室共发表论文近400篇，其中SCI论文100余篇，论文总数及影响因子位居同类学科领域前列。

[1] Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, Zhang F, Wang A, Woodgett JR, Lu Y. Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3beta and beta-catenin. Biochem Pharmacol. 2016.

[2]Tao L, Wang S, Zhao Y, Wang AY, Zhang L, Ruan JS, Fan FT, Liu YP, Li Y, Yue ZQ, Qian WH, Chen WX, Lu Y. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis. Chin J Integr Med. 2016.

[3]Liu Z, Wu H, Wei Z, Wang X, Shen P, Wang S, Wang A, Chen W, Lu Y. TRPM8: a potential target for cancer treatment. J Cancer Res Clin Oncol. 2016.

[4] Zhang F, Lu C, Xu W, Shao J, Wu L, Lu Y, Zheng S. Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2):460-466.

[5]Zhang F, Jin H, Wu L, Shao J, Wu X, Lu Y, Zheng S. Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes. Biomed Pharmacother. 2016; 78204-209.

[6]Zhang F, Chen L, Jin H, Shao J, Wu L, Lu Y, Zheng S. Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity. Environ Toxicol Pharmacol. 2016; 418-13.

[7]Xu W, Lu C, Zhang F, Shao J, Zheng S. Dihydroartemisinin restricts hepatic stellate cell contraction via an FXR-S1PR2-dependent mechanism. IUBMB Life. 2016; 68(5):376-387.

[8]Lian N, Jin H, Zhang F, Wu L, Shao J, Lu Y, Zheng S. Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase. IUBMB Life. 2016; 68(7):589-596.

[9]Jin H, Lian N, Zhang F, Chen L, Chen Q, Lu C, Bian M, Shao J, Wu L, Zheng S. Activation of PPARgamma/P53 signaling is required for curcumin to induce hepatic stellate cell senescence. Cell Death Dis. 2016; 7e2189.

[10]Chen Q, Chen L, Wu X, Zhang F, Jin H, Lu C, Shao J, Kong D, Wu L, Zheng S. Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K/Akt pathway. IUBMB Life. 2016; 68(3):220-231.

[11]Chen Q, Chen L, Kong D, Shao J, Wu L, Zheng S. Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-betaR/ERK signaling pathway. Int Immunopharmacol. 2016; 34250-258.

[12]Chen LY, Chen Q, Zhu XJ, Kong DS, Wu L, Shao JJ, Zheng SZ. Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism. Int Immunopharmacol. 2016; 3623-30.

[13]Chen LY, Chen Q, Cheng YF, Jin HH, Kong DS, Zhang F, Wu L, Shao JJ, Zheng SZ. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. Biomed Pharmacother. 2016; 7935-43.

[14]Zhang Q, Bian H, Guo L, Zhu H. Pharmacologic preconditioning with berberine attenuating ischemia-induced apoptosis and promoting autophagy in neuron. Am J Transl Res. 2016; 8(2):1197-1207.

[15]Lin C, Liu Z, Lu Y, Yao Y, Zhang Y, Ma Z, Kuai M, Sun X, Sun S, Jing Y, Yu L, Li Y, Zhang Q, Bian H. Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis. J Pharm Pharmacol. 2016; 68(7):941-952.

[16]Wu X, Qi X, Lu Y, Lin C, Yuan Y, Zhu Q, Yin Q, Li W, Li Y, Bian H. Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro. Biomed Pharmacother. 2016; 80260-267.

[17]Zhang Q, Lu Y, Ma Z, Li Y, Guo J, Meng Q, Bian H. A novel formula from mulberry leaf ameliorates diabetic nephropathy in rats via inhibiting the TGF-beta1 pathway. Food Funct. 2015; 6(10):3307-3315.

[18]18]Qian W, Tao L, Wang Y, Zhang F, Li M, Huang S, Wang A, Chen W, Yue Z, Chen L, Liu Y, Huang C, Zhang L, Li Y, Lu Y. Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis. J Vasc Res. 2015; 52(3):197-209.

[19]Zhu Z, Zhao Y, Li J, Tao L, Shi P, Wei Z, Sheng X, Shen D, Liu Z, Zhou L, Tian C, Fan F, Shen C, Zhu P, Wang A, Chen W, Zhao Q, Lu Y. Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-alpha mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR. Mol Carcinog. 2015.

[20]Zhang L, Tao L, Shi T, Zhang F, Sheng X, Cao Y, Zheng S, Wang A, Qian W, Jiang L, Lu Y. Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-kappaB and STAT3 pathways. IUBMB Life. 2015; 67(10):778-788.

[21]Yue Z, Wang A, Zhu Z, Tao L, Li Y, Zhou L, Chen W, Lu Y. Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells. Mol Cell Biochem. 2015; 410(1-2):143-154.

[22]Yan LG, Ruan JS, Zhang L, Fan FT, Zhang F, Wang AY, Zheng SZ, Zeng L, Li WL, Lu Y. Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro. Chin J Integr Med. 2015; 21(4):286-290.

[23]Wu H, Fan F, Liu Z, Zhang F, Liu Y, Wei Z, Shen C, Cao Y, Wang A, Lu Y. The angiogenic responses induced by release of angiogenic proteins from tumor cell-activated platelets are regulated by distinct molecular pathways. IUBMB Life. 2015; 67(8):626-633.

[24]Wu H, Fan F, Liu Z, Shen C, Wang A, Lu Y. Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway. Cancer Chemother Pharmacol. 2015; 76(2):307-315.

[25]Liu Z, Zhu P, Tao Y, Shen C, Wang S, Zhao L, Wu H, Fan F, Lin C, Chen C, Zhu Z, Wei Z, Sun L, Liu Y, Wang A, Lu Y. Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice. Food Chem Toxicol. 2015; 811-8.

[26]Liu Z, Shen C, Tao Y, Wang S, Wei Z, Cao Y, Wu H, Fan F, Lin C, Shan Y, Zhu P, Sun L, Chen C, Wang A, Zheng S, Lu Y. Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in mice. Food Chem Toxicol. 2015; 8212-18.

[27]Liu Y, Zhu P, Wang Y, Wei Z, Tao L, Zhu Z, Sheng X, Wang S, Ruan J, Liu Z, Cao Y, Shan Y, Sun L, Wang A, Chen W, Lu Y. Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-kappaB and ERK/MAPK Signaling Pathways. PLoS One. 2015; 10(4):e0123781.

[28]Zhang Z, Zhang F, Lu Y, Zheng S. Update on implications and mechanisms of angiogenesis in liver fibrosis. Hepatol Res. 2015; 45(2):162-178.

[29]Zhang Z, Guo M, Zhao S, Xu W, Shao J, Zhang F, Wu L, Lu Y, Zheng S. The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target. Biomed Pharmacother. 2015; 7417-29.

[30]Wu X, Zhang F, Xiong X, Lu C, Lian N, Lu Y, Zheng S. Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway. IUBMB Life. 2015; 67(4):312-321.

[31]Lu C, Zhang F, Xu W, Wu X, Lian N, Jin H, Chen Q, Chen L, Shao J, Wu L, Lu Y, Zheng S. Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life. 2015; 67(8):645-658.

[32]Lu C, Xu W, Zhang F, Jin H, Chen Q, Chen L, Shao J, Wu L, Lu Y, Zheng S. Ligustrazine prevents alcohol-induced liver injury by attenuating hepatic steatosis and oxidative stress. Int Immunopharmacol. 2015; 29(2):613-621.

[33]Lu C, Jiang Y, Zhang F, Shao J, Wu L, Wu X, Lian N, Chen L, Jin H, Chen Q, Lu Y, Zheng S. Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2. Life Sci. 2015; 141119-127.

[34]Lian N, Jiang Y, Zhang F, Jin H, Lu C, Wu X, Lu Y, Zheng S. Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells. Lab Invest. 2015; 95(7):790-803.

[35]Kong D, Zhang F, Shao J, Wu L, Zhang X, Chen L, Lu Y, Zheng S. Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-beta/Smad signaling in hepatocytes. Lab Invest. 2015; 95(11):1234-1245.

[36]Yu X, Niu Y, Zheng J, Liu H, Jiang G, Chen J, Hong M. Radix Saposhnikovia extract suppresses mouse allergic contact dermatitis by regulating dendritic-cell-activated Th1 cells. Phytomedicine. 2015; 22(13):1150-1158.

[37]Zhou J, Lu G, Wang H, Zhang J, Duan J, Ma H, Wu Q. Molecular structure-affinity relationship of bufadienolides and human serum albumin in vitro and molecular docking analysis. PLoS One. 2015; 10(5):e0126669.

[38]Zhou J, Gong Y, Ma H, Wang H, Qian D, Wen H, Liu R, Duan J, Wu Q. Effect of drying methods on the free and conjugated bufadienolide content in toad venom determined by ultra-performance liquid chromatography-triple quadrupole mass spectrometry coupled with a pattern recognition approach. J Pharm Biomed Anal. 2015; 114482-487.

[39]Liu K, Xu H, Lv G, Liu B, Lee MK, Lu C, Lv X, Wu Y. Loganin attenuates diabetic nephropathy in C57BL/6J mice with diabetes induced by streptozotocin and fed with diets containing high level of advanced glycation end products. Life Sci. 2015; 12378-85.

[40]Liu TY, Zhou LL, Zhou C, Liu ZP, Chen C, Feng Z, Zhou XP. Inhibition mechanism of Qingluo Tongbi Granule () on osteoclast differentiation induced by synovial fibroblast and monocytes co-culture in adjuvant-induced arthritic rats. Chin J Integr Med. 2015; 21(4):291-298.

[41]Yuan DP, Gu L, Long J, Chen J, Ni J, Qian N, Shi YL. Shikonin reduces endometriosis by inhibiting RANTES secretion and mononuclear macrophage chemotaxis. Exp Ther Med. 2014; 7(3):685-690.

[42]Yuan DP, Long J, Lu Y, Lin J, Tong L. The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology. Chin J Nat Med. 2014; 12(6):443-448.

[43]Shen D, Xie X, Zhu Z, Yu X, Liu H, Wang H, Fan H, Wang D, Jiang G, Hong M. Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization. PLoS One. 2014; 9(9):e107279.

[44]Tao L, Wang S, Zhao Y, Sheng X, Wang A, Zheng S, Lu Y. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. Phytomedicine. 2014; 21(11):1473-1482.

[45]Shen C, Wang S, Shan Y, Liu Z, Fan F, Tao L, Liu Y, Zhou L, Pei C, Wu H, Tian C, Ruan J, Chen W, Wang A, Zheng S, Lu Y. Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice. Food Funct. 2014; 5(7):1422-1431.

[46]Liu Z, Fan F, Wang A, Zheng S, Lu Y. Dll4-Notch signaling in regulation of tumor angiogenesis. J Cancer Res Clin Oncol. 2014; 140(4):525-536.

[47]Fan FT, Shen CS, Tao L, Tian C, Liu ZG, Zhu ZJ, Liu YP, Pei CS, Wu HY, Zhang L, Wang AY, Zheng SZ, Huang SL, Lu Y. PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation. Asian Pac J Cancer Prev. 2014; 15(5):1961-1970.

[48]Zhu X, Zhang F, Zhou L, Kong D, Chen L, Lu Y, Zheng S. Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats. Naunyn Schmiedebergs Arch Pharmacol. 2014; 387(5):445-455.

[49]Zhang X, Zhang F, Kong D, Wu X, Lian N, Chen L, Lu Y, Zheng S. Tetramethylpyrazine inhibits angiotensin II-induced activation of hepatic stellate cells associated with interference of platelet-derived growth factor beta receptor pathways. FEBS J. 2014; 281(12):2754-2768.

[50]Zhang F, Zhang Z, Kong D, Zhang X, Chen L, Zhu X, Lu Y, Zheng S. Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways. Mol Cell Endocrinol. 2014; 382(1):197-204.

[51]Zhang F, Zhang Z, Chen L, Kong D, Zhang X, Lu C, Lu Y, Zheng S. Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells. J Cell Mol Med. 2014; 18(7):1392-1406.

[52]Zhang F, Kong D, Chen L, Zhang X, Lian N, Zhu X, Lu Y, Zheng S. Peroxisome proliferator-activated receptor-gamma interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-beta receptor in hepatic stellate cells. J Cell Sci. 2014; 127(Pt 2):305-314.

[53]Li Y, Qi X, Yang YW, Pan Y, Bian HM. Toxic effects of strychnine and strychnine N-oxide on zebrafish embryos. Chin J Nat Med. 2014; 12(10):760-767.

[54]Li Y, Song P, Zhu Q, Yin QY, Ji JW, Li W, Bian HM. Liguzinediol improved the heart function and inhibited myocardial cell apoptosis in rats with heart failure. Acta Pharmacol Sin. 2014; 35(10):1257-1264.

[55]Zhang Q, Bian H, Li Y, Guo L, Tang Y, Zhu H. Preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiates HIF-1alpha-dependent neuroprotection against cerebral ischemia in rats. J Ethnopharmacol. 2014; 154(2):443-452.

[56]Zhang QC, Zhao Y, Bian HM. Anti-thrombotic effect of a novel formula from Corni fructus with malic acid, succinic acid and citric acid. Phytother Res. 2014; 28(5):722-727.

[57]Wu L, Cai B, Liu X, Cai H. Emodin attenuates calcium overload and endoplasmic reticulum stress in AR42J rat pancreatic acinar cells. Mol Med Rep. 2014; 9(1):267-272.

[58]Ma H, Zhou J, Shang E, Zhang J, Lu W, Zhan Z, Qian D, Duan J, Fan X. Interactions between bufadienolides derived from toad venom and verapamil in langendorff-perfused guinea-pig hearts. Toxicol In Vitro. 2013; 27(1):396-401.

[59]Zhang QC, Zhao Y, Bian HM. Antiplatelet activity of a novel formula composed of malic acid, succinic acid and citric acid from Cornus officinalis fruit. Phytother Res. 2013; 27(12):1894-1896.

[60]Zhou L, Zhang K, Li J, Cui X, Wang A, Huang S, Zheng S, Lu Y, Chen W. Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats. Reprod Toxicol. 2013; 3762-69.

[61]Zhao Y, Zhang D, Wang S, Tao L, Wang A, Chen W, Zhu Z, Zheng S, Gao X, Lu Y. Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-kappaB/tissue factor/Factor Xa pathway in melanoma B16F10 cells. PLoS One. 2013; 8(2):e56557.

[626] Wu L, Li H, Zheng SZ, Liu X, Cai H, Cai BC. Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis. J Ethnopharmacol. 2013; 150(3):960-966.

[63]Wu L, Cai B, Zheng S, Liu X, Cai H, Li H. Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis. Inflammation. 2013; 36(5):1020-1029.

[64]Tao L, Fan F, Liu Y, Li W, Zhang L, Ruan J, Shen C, Sheng X, Zhu Z, Wang A, Chen W, Huang S, Lu Y. Concerted suppression of STAT3 and GSK3beta is involved in growth inhibition of non-small cell lung cancer by Xanthatin. PLoS One. 2013; 8(11):e81945.

[65]Chen W, Lu Y, Chen G, Huang S. Molecular evidence of cryptotanshinone for treatment and prevention of human cancer. Anticancer Agents Med Chem. 2013; 13(7):979-987.

[666]Zhang Z, Guo Y, Zhang S, Zhang Y, Wang Y, Ni W, Kong D, Chen W, Zheng S. Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro. Eur J Pharmacol. 2013; 721(1-3):133-140.

[67]Zhang F, Kong DS, Zhang ZL, Lei N, Zhu XJ, Zhang XP, Chen L, Lu Y, Zheng SZ. Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro. Apoptosis. 2013; 18(2):135-149.

[68]Zhang F, Kong D, Lu Y, Zheng S. Peroxisome proliferator-activated receptor-gamma as a therapeutic target for hepatic fibrosis: from bench to bedside. Cell Mol Life Sci. 2013; 70(2):259-276.

[69]Kong D, Zhang F, Zhang Z, Lu Y, Zheng S. Clearance of activated stellate cells for hepatic fibrosis regression: molecular basis and translational potential. Biomed Pharmacother. 2013; 67(3):246-250.

[70]Chen L, Zhang F, Kong D, Zhu X, Chen W, Wang A, Zheng S. Saikosaponin D disrupts platelet-derived growth factor-beta receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity. Chem Biol Interact. 2013; 206(1):76-82.

[71]Hong M, Zheng J, Ding ZY, Chen JH, Yu L, Niu Y, Hua YQ, Wang LL. Imbalance between Th17 and Treg cells may play an important role in the development of chronic unpredictable mild stress-induced depression in mice. Neuroimmunomodulation. 2013; 20(1):39-50.

[72]Ma H, Hong M, Duan J, Liu P, Fan X, Shang E, Su S, Guo J, Qian D, Tang Y. Altered cytokine gene expression in peripheral blood monocytes across the menstrual cycle in primary dysmenorrhea: a case-control study. PLoS One. 2013; 8(2):e55200.

[73]Yu B, Ruan M, Cui XB, Guo JM, Xu L, Dong XP. Effects of borneol on the pharmacokinetics of geniposide in cortex, hippocampus, hypothalamus and striatum of conscious rat by simultaneous brain microdialysis coupled with UPLC-MS. J Pharm Biomed Anal. 2013; 77128-132.

[74]Yu B, Ruan M, Dong X, Yu Y, Cheng H. The mechanism of the opening of the blood-brain barrier by borneol: a pharmacodynamics and pharmacokinetics combination study. J Ethnopharmacol. 2013; 150(3):1096-1108.

[75]Shi L, Xu L, Yang Y, Song H, Pan H, Yin L. Suppressive effect of modified Simiaowan on experimental gouty arthritis: an in vivo and in vitro study. J Ethnopharmacol. 2013; 150(3):1038-1044.

[76]Hong M, Ma HY, Wu XR, Hua YQ, Zhu Q, Fan HW. A method of hepatocyte extraction conjugated with HPLC is established for screening potential active components in Chinese medicines--probing Herba Artemisiae Scopariae as an exemplifying approach. Molecules. 2012; 17(2):1468-1482.

[77]Zhang L, Tao L, Ruan J, Li W, Wu Y, Yan L, Zhang F, Fan F, Zheng S, Wang A, Lu Y. Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 cells. Planta Med. 2012; 78(9):890-895.

[78]Zhang L, Ruan J, Yan L, Li W, Wu Y, Tao L, Zhang F, Zheng S, Wang A, Lu Y. Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-kappaB pathway in A549 non-small-cell lung cancer cells. Molecules. 2012; 17(4):3736-3750.

[79]Yue ZQ, Liu YP, Ruan JS, Zhou L, Lu Y. Tumor-associated macrophages: a novel potential target for cancer treatment. Chin Med J (Engl). 2012; 125(18):3305-3311.

[80]Ruan JS, Liu YP, Zhang L, Yan LG, Fan FT, Shen CS, Wang AY, Zheng SZ, Wang SM, Lu Y. Luteolin reduces the invasive potential of malignant melanoma cells by targeting beta3 integrin and the epithelial-mesenchymal transition. Acta Pharmacol Sin. 2012; 33(10):1325-1331.

[81]Chen W, Liu L, Luo Y, Odaka Y, Awate S, Zhou H, Shen T, Zheng S, Lu Y, Huang S. Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res (Phila). 2012; 5(5):778-787.

[82]Ruan J, Zhang L, Yan L, Liu Y, Yue Z, Chen L, Wang AY, Chen W, Zheng S, Wang S, Lu Y. Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells. Mol Med Rep. 2012; 6(1):232-238.

[83]Zhang XP, Zhang F, Zhang ZL, Ma J, Kong DS, Ni GX, Wang AY, Chen WX, Lu Y, Zheng SZ. Acupuncture combined with curcumin disrupts platelet-derived growth factor beta receptor/extracellular signal-regulated kinase signalling and stimulates extracellular matrix degradation in carbon tetrachloride-induced hepatic fibrosis in rats. Acupunct Med. 2012; 30(4):324-330.

[84]Zhang F, Ni C, Kong D, Zhang X, Zhu X, Chen L, Lu Y, Zheng S. Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-beta receptor-mediated ERK and p38 pathways. Toxicol Appl Pharmacol. 2012; 265(1):51-60.

[85] Zhang F, Ma J, Lu Y, Ni GX, Ni CY, Zhang XJ, Zhang XP, Kong DS, Wang AY, Chen WX, Zheng SZ. Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats. Acupunct Med. 2012; 30(2):132-138.

[86]Zhang F, Lu Y, Zheng S. Peroxisome proliferator-activated receptor-gamma cross-regulation of signaling events implicated in liver fibrogenesis. Cell Signal. 2012; 24(3):596-605.

[87]87]Chen L, Xu Y, Li W, Wu H, Luo Z, Li X, Huang F, Young C, Liu Z, Zhou S. The novel compound liguzinediol exerts positive inotropic effects in isolated rat heart via sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism. Life Sci. 2012; 91(11-12):402-408.

[88]Chen L, Titch T, Luo Z, Xu Y, Li X, Huang F, Liu L, Xiao W, Wu H, Wang Z. Confirmation of a proarrhythmic risk underlying the clinical use of common Chinese herbal intravenous injections. J Ethnopharmacol. 2012; 142(3):829-835.

[89]Wang AY, Lu Y, Zhu HL, Jiao QC. URD12: A urea derivative with marked antitumor activities. Oncol Lett. 2012; 3(2):373-376.

[909] Ma H, Zhou J, Jiang J, Duan J, Xu H, Tang Y, Lv G, Zhang J, Zhan Z, Ding A. The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice. Exp Toxicol Pathol. 2012; 64(5):417-423.

[91]]Ma H, Jiang J, Zhang J, Zhou J, Ding A, Lv G, Xu H, You F, Zhan Z, Duan J. Protective effect of taurine on cardiotoxicity of the bufadienolides derived from toad (Bufo bufo gargarizans Canto) venom in guinea-pigs in vivo and in vitro. Toxicol Mech Methods. 2012; 22(1):1-8.

[92]Ma H, Zhang J, Jiang J, Zhou J, Xu H, Zhan Z, Wu Q, Duan J. Bilirubin attenuates bufadienolide-induced ventricular arrhythmias and cardiac dysfunction in guinea-pigs by reducing elevated intracellular Na(+) levels. Cardiovasc Toxicol. 2012; 12(1):83-89.

[93]Ma H, Su S, Duan J, Tang Y, Zhou J, Guo J, Zhan Z. Evaluation of the analgesic activities of the crude aqueous extract and fractions of Shao Fu Zhu Yu decoction. Pharm Biol. 2011; 49(2):137-145.

[94]Hong M, Wang XZ, Wang L, Hua YQ, Wen HM, Duan JA. Screening of immunomodulatory components in Yu-ping-feng-san using splenocyte binding and HPLC. J Pharm Biomed Anal. 2011; 54(1):87-93.

[95]Yan LG, Lu Y, Zheng SZ, Wang AY, Li MQ, Ruan JS, Zhang L. Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. Am J Chin Med. 2011; 39(2):325-333.

[96]Chen W, Lu Y, Wu J, Gao M, Wang A, Xu B. Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis. Cancer Chemother Pharmacol. 2011; 67(4):799-808.

[97]Chen W, Lu Y, Gao M, Wu J, Wang A, Shi R. Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo. J Ethnopharmacol. 2011; 133(1):220-226.

[98]Chen L, Zheng SZ, Sun ZG, Wang AY, Huang CH, Punchard NA, Huang SL, Gao X, Lu Y. Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Cancer Chemother Pharmacol. 2011; 68(1):17-27.

[99]Zhang LJ, Chen L, Lu Y, Wu JM, Xu B, Sun ZG, Zheng SZ, Wang AY. Danshensu has anti-tumor activity in B16F10 melanoma by inhibiting angiogenesis and tumor cell invasion. Eur J Pharmacol. 2010; 643(2-3):195-201.

[100] Chen W, Luo Y, Liu L, Zhou H, Xu B, Han X, Shen T, Liu Z, Lu Y, Huang S. Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila). 2010; 3(8):1015-1025.

[101]Zhang W, Lu Y, Xu B, Wu J, Zhang L, Gao M, Zheng S, Wang A, Zhang C, Chen L, Lei N. Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro. Cancer Biol Ther. 2009; 8(15):1489-1499.

[102]Chen L, Lu Y, Wu JM, Xu B, Zhang LJ, Gao M, Zheng SZ, Wang AY, Zhang CB, Zhang WW, Lei N. Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor. Biochem Biophys Res Commun. 2009; 386(2):374-379.